反应详情

A solution of 1-methylimidazolidin-2-one (80 mg, 0.82 mM, Heterocycles, 1987, 26, 3153) in dimethylsulfoxide (1 ml) was treated with sodium hydride (55% in oil, 40 mg, 0.92 mM) at ambient temperature under nitrogen. After stirring for 20 minutes, (5R)-3-(4-(3,6-dihydro-2H-pyran-4-yl)-3-fluorophenyl)-5-methanesulfonyloxymethyloxazolidin-2-one (300 mg, 0.81 mM; WO 97-09328) in dimethylsulfoxide (1.5 ml) was added and stirring continued for 1.5 hours. The temperature was then progressively raised to 85°, and heated at this temperature for 24 hours. After cooling and dilution with water (50 ml), the mixture was extracted with ethyl acetate (3×30 ml), and combined extracts washed with brine (20 ml). After drying (magnesium sulfate) and evaporation, the residue was purified by chromatography on a 10 g silica Mega Bond Elut® column, eluting with a gradient increasing in polarity from 0 to 6% methanol in dichloromethane. Relevant fractions were combined to give the title product (60 mg).

1. stirringstirring
2. waitcontinued for 1.5 hours
3. temperatureThe temperature was then progressively raised to 85°
4. temperatureheated at this temperature for 24 hours
5. temperatureAfter cooling
6. extractiondilution with water (50 ml), the mixture was extracted with ethyl acetate (3×30 ml)
7. washwashed with brine (20 ml)
8. customAfter drying
9. custom(magnesium sulfate) and evaporation
10. customthe residue was purified by chromatography on a 10 g silica Mega Bond Elut® column
11. washeluting with
12. temperaturea gradient increasing in polarity from 0 to 6% methanol in dichloromethane