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(5R)-3-(4-(1,2,5,6-Tetrahydropyridin-4-yl)-3-fluorophenyl)-5-(1,2,3-triazol-1-ylmethyl)-oxazolidin-2-one hydrochloride (380 mg, 1 mM) was suspended in dichloromethane (15 ml), 4-dimethylaminopyridine (305 mg, 2.5 mM) added, and the mixture stirred vigorously for 15 minutes. After cooling to 0° C. under nitrogen, methanesulfonyl chloride (229 mg, 2 mM) was added dropwise, and the mixture stirred 18 hours at ambient temperature. Precipitated solid was removed, and the organic solution concentrated, then purified by chromatography on a 10 g silica Mega Bond Elut® column, eluting with a gradient increasing in polarity from 0 to 5% methanol in dichloromethane. Relevant fractions were combined and evaporated to give the desired product (30 mg). MS (ESP): 422 (MH+) for C18H20FN5O4S

1. stirringthe mixture stirred 18 hours at ambient temperature
2. customPrecipitated solid
3. customwas removed
4. concentrationthe organic solution concentrated
5. custompurified by chromatography on a 10 g silica Mega Bond Elut® column
6. washeluting with
7. temperaturea gradient increasing in polarity from 0 to 5% methanol in dichloromethane
8. customevaporated