2-Methoxyethane-1-sulfonyl chloride → HCID 69363416, compound

HRID 723804Notes

Reaction equation

HRID 723804 reaction equation
Cl.[NH:2]1[CH2:7][CH2:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([N:14]3[CH2:18][C@H:17]([CH2:19][N:20]4[CH:24]=[CH:23][N:22]=[N:21]4)[O:16][C:15]3=[O:25])=[CH:10][C:9]=2[F:26])=[CH:4][CH2:3]1.[CH3:27][O:28][CH2:29][CH2:30][S:31](Cl)(=[O:33])=[O:32]>>[CH3:27][O:28][CH2:29][CH2:30][S:31]([N:2]1[CH2:7][CH2:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([N:14]3[CH2:18][C@H:17]([CH2:19][N:20]4[CH:24]=[CH:23][N:22]=[N:21]4)[O:16][C:15]3=[O:25])=[CH:10][C:9]=2[F:26])=[CH:4][CH2:3]1)(=[O:33])=[O:32]

Participants

3

Reactant 2

HCID 134802212-Methoxyethane-1-sulfonyl chlorideHCID 69364214HCID 69364214, compound

Product 1

HCID 69363416HCID 69363416, compound

Procedure

(5R)-3-(4-(1,2,5,6-Tetrahydropyridin-4-yl)-3-fluorophenyl)-5-(1,2,3-triazol-1-ylmethyl)-oxazolidin-2-one hydrochloride (380 mg, 1 mM) was treated with 2-methoxyethylsulfonyl chloride essentially as in Example 79. Chromatography gave the desired product (65 mg).

Sources & evidence

ORD record
ord-801c896614294ce289bc99f34a08504c
Source dataset
uspto-grants-2006_11
Patent number
US07141583B2

Reaction notes

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