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HRID72381

反应详情

EQUATION

反应方程式

HRID 72381 的结构方程式

REACTANTS

反应物

3
结构：O=C([O-])[O-].[Cs+].[Cs+]
HCID10796

Cesium carbonate

CCs2O3

结构：FC(F)(F)c1cc(Cl)c2cc(CBr)ccc2n1
HCID2736346

6-(bromomethyl)-4-chloro-2-(trifluoromethyl)quinoline

C11H6BrClF3N

结构：C[C@@]1(C(F)(F)F)Cn2c(nc(N3CCOCC3)cc2=O)N1
HCID136069602

未命名化合物

PRODUCTS

生成物

1
结构：C[C@@]1(C(F)(F)F)Cn2c(nc(N3CCOCC3)cc2=O)N1Cc1ccc2nc(C(F)(F)F)cc(Cl)c2c1.O=C(O)C(F)(F)F
HCID86666038

未命名化合物

PROCEDURE

实验过程

The product is prepared according to the procedure described in stage k of Example 1, using 95 mg of (2S)-2-methyl-7-(morpholin-4-yl)-2-(trifluoromethyl)-2,3-dihydroimidazo[1,2-a]pyrimidin-5(1H)-one (Example 1j) and 101 mg of 6-(bromomethyl)-4-chloro-2-(trifluoromethyl)quinoline, replacing the sodium hydride with 203 g of caesium carbonate. After purification by preparative HPLC/MS (method C), 40 mg of (2S)-1-{[4-chloro-2-(trifluoromethyl)quinolin-6-yl]methyl}-2-methyl-7-(morpholin-4-yl)-2-(trifluoromethyl)-2,3-dihydroimidazo[1,2-a]pyrimidin-5(1H)-one, in the form of a trifluoroacetic acid salt, are obtained in the form of a beige powder, the characteristics of which are the following:

WORKUP

后处理

  1. customThe product is prepared
  2. customAfter purification by preparative HPLC/MS (method C), 40 mg of (2S)-1-{[4-chloro-2-(trifluoromethyl)quinolin-6-yl]methyl}-2-methyl-7-(morpholin-4-yl)-2-(trifluoromethyl)-2,3-dihydroimidazo[1,2-a]pyrimidin-5(1H)-one