HCID 2653166, compound → HCID 21878237, compound

Participants

Reaction Steps

Into a round-bottomed flask equipped with a condenser was placed 6-chloro-N-(4-fluoro-phenyl)-nicotinamide (0.20 g, 0.80 mmol), tetrahydrofuran (6 mL), and sodium thioethoxide (0.10 g, 1.2 mmol). The mixture was heated to reflux for 4 h at which time additional sodium thioethoxide (0.10 g, 1.2 mmol) was added and stirred for 2 additional hours. The reaction mixture was then cooled and poured into ice water and the solids isolated by vacuum filtration to provide 0.15 g (68%) of the product as a white solid. MS (EI) m/z 275.2 (M−H)−.

Provenance & Evidence