Ammonia → HCID 9906029, compound

HRID 723867Notes

Reaction equation

HRID 723867 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]2[CH2:7][N:8]([C:10]3[CH:15]=[CH:14][C:13]([N:16]4[CH2:20][C@H:19]([C:21]([O:23]C)=O)[O:18][C:17]4=[O:25])=[CH:12][C:11]=3[F:26])[CH2:9][C:2]=12.[NH3:27]>CO>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]2[CH2:7][N:8]([C:10]3[CH:15]=[CH:14][C:13]([N:16]4[CH2:20][C@H:19]([C:21]([NH2:27])=[O:23])[O:18][C:17]4=[O:25])=[CH:12][C:11]=3[F:26])[CH2:9][C:2]=12

Participants

4

Reactant 2

HCID 222AmmoniaHCID 68489806HCID 68489806, compound

Product 1

HCID 9906029HCID 9906029, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The methyl (5R)-3-[4-(5,7-dihydro-6H-pyrrolo[3,4-b]pyridin-6-yl)-3-fluorophenyl]-2-oxo-5-oxazolidinecarboxylate (Step 1) is suspended in saturated ammonia in methanol (25 mL), stirred at ambient temperature for 4 h and filtered to give the title compound, mp 257° C. (dec.); MS (ESI+) for C17H15N4O3F m/z 343 (M+H)+.

Workup

  1. filtrationfiltered

Sources & evidence

ORD record
ord-6c08e6a05a2d410f8272d7649baafb0c
Source dataset
uspto-grants-2006_11
Patent number
US07141588B2

Reaction notes

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