Trifluoromethanesulfonic acid, lithium salt → HCID 86610081, compound

HRID 723931Notes

Reaction equation

HRID 723931 reaction equation
[NH2:1][C:2]1[CH:13]=[C:12]([F:14])[C:5]2[N:6]([CH2:10][CH3:11])[C:7](=[O:9])[O:8][C:4]=2[CH:3]=1.[CH3:15][O:16][C:17]([C@@H:19]1[O:21][CH2:20]1)=[O:18].FC(F)(F)S([O-])(=O)=O.[Li+]>C(#N)C>[CH2:10]([N:6]1[C:5]2[C:12]([F:14])=[CH:13][C:2]([NH:1][CH2:20][C@@H:19]([OH:21])[C:17]([O:16][CH3:15])=[O:18])=[CH:3][C:4]=2[O:8][C:7]1=[O:9])[CH3:11]

Participants

5

Reactant 3

HCID 3664839Trifluoromethanesulfonic acid, lithium saltHCID 9877347Methyl (2R)-2-oxiranecarboxylateHCID 68490571HCID 68490571, compound

Product 1

HCID 86610081HCID 86610081, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Prepared from 6-amino-3-ethyl-4-fluoro-1,3-benzoxazol-2(3H)-one (Step 2, 0.90 g, 4.59 mmol), methyl (2R)-glycidate (0.469 g, 4.59 mmol) and lithium trifluoromethanesulfonate (0.716 g, 4.59 mmol) in acetonitrile (10 ml) according to the method of EXAMPLE 86, Step 8 (1.11 g, 81%); MS for C13H15FN2O5 m/z 299 (M+H)+.

Sources & evidence

ORD record
ord-695e9614f4414f599ef004b76595b317
Source dataset
uspto-grants-2006_11
Patent number
US07141588B2

Reaction notes

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