反应详情

6-Amino-2-(2-pyrrolidin-1-yl-ethylamino)benzothiazole (Example 12, 28 mg, 0.11 mmol) and thiophene-2-carboximidothioic acid phenyl ester hydrobromide (32 mg, 0.11 mmol) in 3 mL of ethanol (denatured) was stirred at room temperature for 20 hours. The solvent was removed and the residue was partitioned between 5 mL of H2O and 10 mL of Et2O. The aqueous layer was concentrated to give the title compound. 1H-NMR (CD3OD): δ 8.08 (m, 2H); 7.72 (d, 1H, J=2.0 Hz); 7.64 (d, 1H, J=8.0 Hz); 7.30 (m, 2H); 3.86 (t, 2H, J=5.9 Hz); 3.50 (m, 6H); 2.10 (m, 4H).

1. customThe solvent was removed
2. customthe residue was partitioned between 5 mL of H2O and 10 mL of Et2O
3. concentrationThe aqueous layer was concentrated