2-Chloro-6-nitrobenzothiazole → HCID 21878473, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of 2-chloro-6-nitrobenzothiazole (1.00 g, 4.66 mmol) in water (9.0 mL) was added 2-morpholin-4-yl-ethylamine (2.45 mL, 18.6 mmol). The dark reaction mixture was stirred under argon and refluxed for 4.5 hours at which time the reaction became red-brown in colour. The mixture was then cooled to 65° C. and stirred an additional 17.75 hours. The precipitate was then collected by suction filtration after cooling to room temperature giving a yellow solid (377 mg, 26%). 1H NMR (DMSO-d6) δ: 8.69 (d, 1H, J=2.1 Hz), 8.10 (dd, 1H, J=2.1, 8.9 Hz), 7.46 (d, 1H, J=8.9 Hz), 3.59 (m, 6H), 2.55 (t, 2H, J=6.2 Hz), 2.51 (m, 4H), 2.43 (m, 4H).

Provenance & Evidence