Chloride → HCID 131726109, compound

Participants

Reaction Steps

To a solution of tert-butyl 3-[2-(cyclopentylamino)-4-pyrimidinyl]-2-(4-fluorophenyl)pyrazolo[1,5-α]pyridin-6-ylcarbamate (35 mg, 0.072 mmol) in dichloromethane was addedhydrogen chloride (144 μL, 4 N in dioxane, 0.58 mmol). The reaction mixture was stirred at room temperature for 18 hours. The reaction mixture was diluted with ether and the precipitated solids were collected on a filter to provide 3-[2-(cyclopentylamino)-4-pyrimidinyl]-2-(4-fluorophenyl)pyrazolo[1,5-α]pyridin-6-amine dihydrochloride (9 mg, 27%) as a brownish yellow solid. 1H NMR (300 MHz, DMSO-d6) δ 8.25 (br, 1H), 7.97–7.91 (m, 2H), 7.53 (m, 2H), 7.26 (t, 2H), 7.06 (d, 1H), 6.15 (br, 1H), 4.14–3.85 (br, 1H), 1.85 (br, 2H), 1.65 (br, 2H), 1.48 (br, 4H); MS m/z 389 (M+1).

Provenance & Evidence