4-Aminophenethyl alcohol → 2-{4-[(5,6-Dichloro-3-nitro-2-pyridinyl)amino]phenyl}ethanol

HRID 724050Notes

Reaction equation

HRID 724050 reaction equation
[N+:1]([C:4]1[C:5](Cl)=[N:6][C:7]([Cl:11])=[C:8]([Cl:10])[CH:9]=1)([O-:3])=[O:2].[NH2:13][C:14]1[CH:19]=[CH:18][C:17]([CH2:20][CH2:21][OH:22])=[CH:16][CH:15]=1>>[Cl:10][C:8]1[CH:9]=[C:4]([N+:1]([O-:3])=[O:2])[C:5]([NH:13][C:14]2[CH:19]=[CH:18][C:17]([CH2:20][CH2:21][OH:22])=[CH:16][CH:15]=2)=[N:6][C:7]=1[Cl:11]

Participants

3

Reactant 2

HCID 669044-Aminophenethyl alcoholHCID 122593792,3,6-Trichloro-5-nitropyridine

Product 1

HCID 218761602-{4-[(5,6-Dichloro-3-nitro-2-pyridinyl)amino]phenyl}ethanol

Procedure

The title compound was prepared according to the procedure described in step 1 of Example 34 from 3-nitro-2,5,6-trichloropyridine (Horn, U.; Mutterer, F.; Weis, C. D. Helv. Chim. Acta., 1976, 59, 190.) and 4-aminophenylethyl alcohol.

Sources & evidence

ORD record
ord-8ece4c128a3e4bd69436f586af606cf9
Source dataset
uspto-grants-2006_11
Patent number
US07141580B2

Reaction notes

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