HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Oxo-azetidine-1-carboxylic acid tert-butyl ester → tert-Butyl 3-(4-fluorophenyl)-3-hydroxyazetidine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Oxo-azetidine-1-carboxylic acid tert-butyl ester | HCID 1519404 | — |
| Reactant | HCID 178418676 | HCID 178418676 | — |
| Product | tert-Butyl 3-(4-fluorophenyl)-3-hydroxyazetidine-1-carboxylate | HCID 65813955 | 110.7% |
Reaction Steps
The title compound (D29) (819.5 mg) was prepared according to the experimental procedure described in Description 28 starting from 1-Boc-3-azetidinone (500 mg, 2.77 mmol) and 4-Fluorophenylmagnesiumbromide (2M in diethylether) (1.67 ml, 3.33 mmol)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08828987B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-0ce4e0a2480c433d9896be7d1fb93e51 |
| Source note | uspto-grants-2014_09 |