4-Aminophenethyl alcohol → 6-[4-(2-Hydroxyethyl)anilino]-2,4-dimethyl-5-nitronicotinonitrile

HRID 724060Notes

Reaction equation

HRID 724060 reaction equation
Cl[C:2]1[C:9]([N+:10]([O-:12])=[O:11])=[C:8]([CH3:13])[C:5]([C:6]#[N:7])=[C:4]([CH3:14])[N:3]=1.[NH2:15][C:16]1[CH:21]=[CH:20][C:19]([CH2:22][CH2:23][OH:24])=[CH:18][CH:17]=1>>[OH:24][CH2:23][CH2:22][C:19]1[CH:20]=[CH:21][C:16]([NH:15][C:2]2[C:9]([N+:10]([O-:12])=[O:11])=[C:8]([CH3:13])[C:5]([C:6]#[N:7])=[C:4]([CH3:14])[N:3]=2)=[CH:17][CH:18]=1

Participants

3

Reactant 2

HCID 669044-Aminophenethyl alcoholHCID 218761896-Chloro-2,4-dimethyl-5-nitronicotinonitrile

Product 1

HCID 218758146-[4-(2-Hydroxyethyl)anilino]-2,4-dimethyl-5-nitronicotinonitrile

Procedure

The title compound was prepared according to the procedure described in step 3 of Example 1 from 6-chloro-2,4-dimethyl-5-nitronicotinonitrile (step 3) and 4-aminophenylethyl alcohol.

Sources & evidence

ORD record
ord-23c289fd39024e3193569b043f2281a5
Source dataset
uspto-grants-2006_11
Patent number
US07141580B2

Reaction notes

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