4-Aminophenethyl alcohol → 3-[4-(2-Hydroxyethyl)anilino]-4-nitrobenzonitrile

HRID 724076Notes

Reaction equation

HRID 724076 reaction equation
Cl[C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[N+:10]([O-:12])=[O:11])[C:5]#[N:6].[NH2:13][C:14]1[CH:19]=[CH:18][C:17]([CH2:20][CH2:21][OH:22])=[CH:16][CH:15]=1>>[OH:22][CH2:21][CH2:20][C:17]1[CH:18]=[CH:19][C:14]([NH:13][C:2]2[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=2[N+:10]([O-:12])=[O:11])[C:5]#[N:6])=[CH:15][CH:16]=1

Participants

3

Reactant 2

HCID 669044-Aminophenethyl alcoholHCID 149730283-Chloro-4-nitrobenzonitrile

Product 1

HCID 218761053-[4-(2-Hydroxyethyl)anilino]-4-nitrobenzonitrile

Procedure

The title compound was prepared according to the procedure described in step 3 of Example 1 from 3-chloro-4-nitrobenzonitrile (Tsuji, K. Chem. Pharm. Bull. 1992, 40, 2399) and 4-aminophenylethyl alcohol.

Sources & evidence

ORD record
ord-721a66220b87462aaf26f235400af9c4
Source dataset
uspto-grants-2006_11
Patent number
US07141580B2

Reaction notes

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