HCID 67099131, compound → HCID 23125737, compound

HRID 724153Notes

Reaction equation

HRID 724153 reaction equation
[Cl:1][C:2]1[C:3]([C:22]([F:25])([F:24])[F:23])=[CH:4][C:5]2[N:9]=[C:8]([CH2:10][CH3:11])[N:7]([C:12]3[CH:13]=[CH:14][C:15]([CH2:18][C:19]#[N:20])=[N:16][CH:17]=3)[C:6]=2[CH:21]=1>[Ni]>[Cl:1][C:2]1[C:3]([C:22]([F:23])([F:24])[F:25])=[CH:4][C:5]2[N:9]=[C:8]([CH2:10][CH3:11])[N:7]([C:12]3[CH:13]=[CH:14][C:15]([CH2:18][CH2:19][NH2:20])=[N:16][CH:17]=3)[C:6]=2[CH:21]=1

Participants

3

Reactant 1

HCID 67099131HCID 67099131, compound

Product 1

HCID 23125737HCID 23125737, compound

Reagents, catalysts & solvents 1

HCID 935NickelCatalyst

Procedure

To a solution of {5-[6-chloro-2-ethyl-5-(trifluoromehyl)-1H-benzimidazol-1-yl]-2-pyridinyl}acetonitrile added Raney-Ni and stirred for 8 h under hydrogen atmosphere (3.0 kgf/cm2). The catalyst was filtered off and the solvent was removed. The residue was diluted with ethyl acetate, washed with brine, dried (MgSO4) and concentrated to give 813 mg of title compound as black solid.

Workup

  1. filtrationThe catalyst was filtered off
  2. customthe solvent was removed
  3. additionThe residue was diluted with ethyl acetate
  4. washwashed with brine
  5. dry with materialdried (MgSO4)
  6. concentrationconcentrated

Sources & evidence

ORD record
ord-3babbf94b78944ffaaae094c396099e3
Source dataset
uspto-grants-2006_11
Patent number
US07141580B2

Reaction notes

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