反应详情

To a solution of 4-chloro-2-methylbenzonitrile (10 g, 66 mmol) in conc. H2SO4 was added KNO3 (7.0 g, 69.3 mmol) at 0° C. in small portions, and then the reaction mixture was stirred overnight at ambient temperature. It was then poured into ice and extracted with AcOEt. The combined extracts were washed by sat. NaHCO3 aq., dried over MgSO4 and concentrated. The resulting precipitates were collected by filtration, washed with ether, and dried under reduced pressure to give 5.5 g (42%) of the title compound.

1. additionIt was then poured into ice
2. extractionextracted with AcOEt
3. washThe combined extracts were washed by sat. NaHCO3 aq.
4. dry with materialdried over MgSO4
5. concentrationconcentrated
6. customThe resulting precipitates
7. filtrationwere collected by filtration
8. washwashed with ether
9. customdried under reduced pressure