3-Fluorophenol → Tert-butyl 3-((3-fluorophenoxy)methyl)piperidine-1-carboxylate

HRID 72419Notes

Reaction equation

HRID 72419 reaction equation
[OH:1][CH2:2][CH:3]1[CH2:8][CH2:7][CH2:6][N:5]([C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])[CH2:4]1.[F:16][C:17]1[CH:18]=[C:19](O)[CH:20]=[CH:21][CH:22]=1>>[F:16][C:17]1[CH:22]=[C:21]([CH:20]=[CH:19][CH:18]=1)[O:1][CH2:2][CH:3]1[CH2:8][CH2:7][CH2:6][N:5]([C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])[CH2:4]1

Participants

3

Reactant 2

HCID 97433-FluorophenolHCID 2763851tert-Butyl 3-(hydroxymethyl)piperidine-1-carboxylate

Product 1

HCID 67958503Tert-butyl 3-((3-fluorophenoxy)methyl)piperidine-1-carboxylate

Procedure

The title compound (D45) (244.9 mg) was prepared according to the experimental procedure described in Description 40 starting from tert-butyl 3-(hydroxymethyl)piperidine-1-carboxylate (200 mg, 0.929 mmol, available at Aldrich#681318) and 3-Fluorophenol (0.083 ml, 0.929 mmol).

Sources & evidence

ORD record
ord-3c80fae67b364db3867226043961eb23
Source dataset
uspto-grants-2014_09
Patent number
US08828987B2

Reaction notes

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