HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trimethyl((tributylstannyl)ethynyl)silane → 2-(3-Fluoro-4-hydroxyphenyl)-4-[(trimethylsilyl)ethynyl]quinolin-6-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trimethyl((tributylstannyl)ethynyl)silane | HCID 639663 | — |
| Reactant | 4-Bromo-2-(3-fluoro-4-hydroxyphenyl)quinolin-6-ol | HCID 135477943 | — |
| Product | 2-(3-Fluoro-4-hydroxyphenyl)-4-[(trimethylsilyl)ethynyl]quinolin-6-ol | HCID 135508430 | 94% |
Reaction Steps
This compound was prepared from 6b and (trimethylsilylethynyl)tributyltin according to method J. Red powder; Yield: 94%; 1H-NMR (300 MHz, acetone-d6) δ 0.43 (s, 9H), 7.21 (dd, J=8.8, 8.8 Hz, 1H), 7.51 (dd, J=9.1, 2.7 Hz, 1H), 7.68 (d, J=2.7 Hz, 1H), 8.05 (m, 1H), 8.07 (d, J=9.0 Hz, 1H), 8.13 (s, 1H), 8.18 (dd, J=12.8, 2.1 Hz, 1H), 9.05 (s, 1H), 9.26 (s, 1H); MS (ESI) m/z 350 ([M−H]−), 352 ([M+H]+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07084276B2 |
| Source dataset | uspto-grants-2006_08 |
| ORD ID | ord-9fbcc659dc29475ebabf18f9a67dbd15 |
| Source note | uspto-grants-2006_08 |