HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclobutylamine → HCID 21879614, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclobutylamine | HCID 75645 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | 1-Hydroxybenzotriazole hydrate | HCID 2796029 | — |
| Reactant | 6-Bromo-2-naphthalenecarboxylic acid | HCID 4549852 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 21879614 | HCID 21879614 | 72.7% |
Reaction Steps
By reactions similar to those in Reference Example 2, using 6-bromo-2-naphthoic acid (1.01 g), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (0.92 g), 1-hydroxy-1H-benzotriazole monohydrate (0.735 g; HOBt), dimethylformamide (16 ml), N-ethyldiisopropylamine (0.62 g) and cyclobutylamine (0.45 g), the title compound (0.89 g) was obtained as colorless needle crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07141598B2 |
| Source dataset | uspto-grants-2006_11 |
| ORD ID | ord-c60f60ff1cfb40119bce77b0e3e89e01 |
| Source note | uspto-grants-2006_11 |