Trityl chloride → HCID 21879616, compound

Participants

Reaction Steps

4-Hydroxy-1-(1H-imidazol-4-yl)butan-1-one (9.23 g) was dissolved in N,N′-dimethylformamide (120 ml), and triethylamine (12.5 ml) and chlorotriphenylmethane (16.69 g) were added. The mixture was stirred at room temperature for 2 h. Brine was added and the mixture was extracted with ethyl acetate. The organic layer was dried over magnesium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent; ethyl acetate:hexane=9:1) to give the title compound (25.22 g) as an orange oil.

Provenance & Evidence