3-(Trifluoromethyl)phenol → 3-[3-(Trifluoromethyl)phenoxy]azetidine

HRID 72424Notes

Reaction equation

HRID 72424 reaction equation
C([N:8]1[CH2:11][CH:10]([OH:12])[CH2:9]1)(OC(C)(C)C)=O.[F:13][C:14]([F:23])([F:22])[C:15]1[CH:16]=[C:17](O)[CH:18]=[CH:19][CH:20]=1>>[F:13][C:14]([F:23])([F:22])[C:15]1[CH:20]=[C:19]([CH:18]=[CH:17][CH:16]=1)[O:12][CH:10]1[CH2:9][NH:8][CH2:11]1

Participants

3

Reactant 2

HCID 73763-(Trifluoromethyl)phenolHCID 2756801Tert-butyl 3-hydroxyazetidine-1-carboxylate

Product 1

HCID 111385383-[3-(Trifluoromethyl)phenoxy]azetidineYield 8%

Procedure

The title compound (D53) (100 mg) was prepared according to the experimental procedure described in Description 52 starting from 1-Boc-3-hydroxyazetidine (1 g, 5.77 mmol) and 3-(Trifluoromethyl)phenol (0.69 ml, 5.77 mmol).

Sources & evidence

ORD record
ord-4c56f6efe6d34c7cb22aed7d2cf12c39
Source dataset
uspto-grants-2014_09
Patent number
US08828987B2

Reaction notes

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