反应详情

cis-2-Amino-1-cyclohexane carboxylic acid (2500 mg, 17.5 mmol) was suspended in methanol (30 ml) at 0° C. Gaseous hydrochloric acid was bubbled through the suspension for 10 minutes. The reaction was allowed to reach room temperature then stirred under nitrogen for 1 h and the solvent removed under reduced pressure. The residue was azeotroped with diethyl ether (2×20 ml) and dried to give the title compound as a solid.

1. customGaseous hydrochloric acid was bubbled through the suspension for 10 minutes
2. customto reach room temperature
3. customthe solvent removed under reduced pressure
4. customThe residue was azeotroped with diethyl ether (2×20 ml)
5. customdried