HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Hydroxyazetidine hydrochloride → Methyl 2-(3-hydroxyazetidin-1-yl)-5-(trifluoromethyl)nicotinate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Hydroxyazetidine hydrochloride | HCID 2759290 | — |
| Reactant | Methyl 2-chloro-5-(trifluoromethyl)nicotinate | HCID 72943191 | — |
| Product | Methyl 2-(3-hydroxyazetidin-1-yl)-5-(trifluoromethyl)nicotinate | HCID 67958859 | 82.6% |
Reaction Steps
The title compound (D67) (4.0 g) was prepared according to the experimental procedure described in Description 62 starting from azetidin-3-ol hydrochloride (2.3 g, 21.03 mmol) and methyl 2-chloro-5-(trifluoromethyl)nicotinate (D66) (4.2 g, 17.53 mmol)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08828987B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-a3e2fe36357b49219f228d8d1e090ab4 |
| Source note | uspto-grants-2014_09 |