HCID 178503223, compound → HCID 178503207, compound

Participants

Reaction Steps

trans-N-{4-[(5-Chloropentanoyl)amino]cyclohexyl}-5-fluoro-2-[3-(methylsulfanyl)phenoxy]nicotinamide (220 mg, 0.405 mmol) was dissolved in dimethylformamide (5 ml) sodium hydride 60% dispersion in oil (41 mg, 1.01 mmol) was added. The reaction was stirred under nitrogen at room temperature for 18 h and the solvent was removed under reduced pressure. The residue was partitioned between sat. sodium hydrogen carbonate solution (10 ml) and dichloromethane (15 ml) and the aqueous phase was extracted with dichloromethane (3×15 ml). The combined organic extracts were washed with water (2×10 ml), brine (10 ml), dried over MgSO4 and the solvent was removed under reduced pressure. The residue was triturated with diethylether (5 ml) to give the title compound (78 mg) as a white solid.

Provenance & Evidence