Water → HCID 58746193, compound

Participants

Reaction Steps

Oxone™ (245 mg, 0.40 mmol) was added to a solution of 5-fluoro-N-[(1S,2R)-2-hydroxycyclohexyl]-2-[3-(methylsulfanyl)phenoxy]nicotinamide (50 mg, 0.13 mmol) in a mixture of isopropanol (2 ml), tetrahydrofurann (1 ml) and water (1 ml) at 0° C. The mixture was warmed to ambient temperature and stirred for 18 h then partitioned between water (2 ml) and dichloromethane (10 ml) using a Chemelute™ cartridge. The organic phase was evaporated and the residue purified by flash column chromatography using dichloromethane:methanol (98:2) as eluant to give 5-fluoro-N-[(1S,2R)-2-hydroxycyclohexyl]-2-[3-(methylsulfonyl)phenoxy]nicotinamide (39 mg) as a colourless glass.

Provenance & Evidence