HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Hydroxyazetidine hydrochloride → Methyl 5-fluoro-2-(3-hydroxyazetidin-1-yl)nicotinate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Hydroxyazetidine hydrochloride | HCID 2759290 | — |
| Reactant | Methyl 2-chloro-5-fluoronicotinate | HCID 24229209 | — |
| Product | Methyl 5-fluoro-2-(3-hydroxyazetidin-1-yl)nicotinate | HCID 67958513 | — |
Reaction Steps
The title compound (D70) (75 mg) was prepared according to the experimental procedure described in Description 62 starting from azetidin-3-ol hydrochloride (208 mg, 1.89 mmol) and methyl 2-chloro-5-fluoronicotinate (300 mg, 1.58 mmol, commercially available from Adesis#2-482).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08828987B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-9f50c0c70a1044b5ab00b3b845761f4a |
| Source note | uspto-grants-2014_09 |