HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 2,5-Dichloronicotinate → Methyl 5-chloro-2-(3-(4-(trifluoromethyl)phenoxy)azetidin-1-yl)nicotinate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 2,5-Dichloronicotinate | HCID 2764318 | — |
| Reactant | 3-[4-(Trifluoromethyl)phenoxy]azetidine | HCID 12812499 | — |
| Product | Methyl 5-chloro-2-(3-(4-(trifluoromethyl)phenoxy)azetidin-1-yl)nicotinate | HCID 67958398 | 66.7% |
Reaction Steps
The title compound (D78) (200 mg) was prepared according to the experimental procedure described in Description 62 starting from Methyl 2,5-dichloronicotinate (160 mg, 0.775 mmol) and 3-(4-(trifluoromethyl)phenoxy)azetidine (D52) (202.13 mg, 0.903 mmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08828987B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-b6292d67aaff47f0bb1b6beedde8dae3 |
| Source note | uspto-grants-2014_09 |