HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 2,5-Dichloronicotinate → Methyl 5-chloro-2-(3-(4-fluorophenyl)-3-hydroxyazetidin-1-yl)nicotinate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 2,5-Dichloronicotinate | HCID 2764318 | — |
| Reactant | tert-Butyl 3-(4-fluorophenyl)-3-hydroxyazetidine-1-carboxylate | HCID 65813955 | — |
| Product | Methyl 5-chloro-2-(3-(4-fluorophenyl)-3-hydroxyazetidin-1-yl)nicotinate | HCID 67958200 | 60.3% |
Reaction Steps
The title compound (D81) (0021/074/1) (75.9 mg) was prepared according to the experimental procedure described in Description 80 starting from tert-butyl 3-(4-fluorophenyl)-3-hydroxyazetidine-1-carboxylate (D29) (100 mg, 0.374 mmol) and methyl 2,5-dichloronicotinate (77.32 mg, 0.374 mmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08828987B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-d3bb85cc8ad3477ba58a356b34090d63 |
| Source note | uspto-grants-2014_09 |