3-Fluorophenol → HCID 67958839, compound

HRID 72443Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[N:4][C:5]([N:12]2[CH2:15][CH:14]([CH2:16][OH:17])[CH2:13]2)=[C:6]([CH:11]=1)[C:7]([O:9][CH3:10])=[O:8].[F:18][C:19]1[CH:20]=[C:21](O)[CH:22]=[CH:23][CH:24]=1>>[Cl:1][C:2]1[CH:3]=[N:4][C:5]([N:12]2[CH2:13][CH:14]([CH2:16][O:17][C:23]3[CH:22]=[CH:21][CH:20]=[C:19]([F:18])[CH:24]=3)[CH2:15]2)=[C:6]([CH:11]=1)[C:7]([O:9][CH3:10])=[O:8]

Participants

Reactant 2

HCID 97433-Fluorophenol

HCID 67958167HCID 67958167, compound

Product 1

HCID 67958839HCID 67958839, compoundYield 132%

Procedure

The title compound (D83) (D021/006/3) (66.2 mg) was prepared according to the experimental procedure described in Description 82 starting from methyl 5-chloro-2-(3-(hydroxymethyl)azetidin-1-yl)nicotinate (D65) (37 mg, 0.143 mmol) and 3-Fluorophenol (13 μl, 0.143 mmol).

Sources & evidence

ORD record: ord-09fc1215e6c84a339685d32826f83df2
Source dataset: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08828987B2

Reaction notes

Loading…