2,2,2-Trifluoroethyl trifluoromethanesulfonate → HCID 11407971, compound

Participants

Reaction Steps

A mixture of 2-(2-chlorophenyl)-3-(4-chlorophenyl)-2H-pyrazolo[3,4-c]pyridin-7-ol (I-9A-1b: 150 mg, 0.421 mmol), 2,2,2-trifluoroethyl trifluoromethanesulfonate (107 mg, 0.463 mmol) and CS2CO3 (151 mg, 0.463 mmol) in DMF (2.1 ml) were stirred overnight at room temperature. The reaction mixture was extracted from saturated aqueous NaHCO3 with ethyl acetate. The combined organic layers were washed with brine, dried (MgSO4), concentrated in vacuo, and then purified on a Biotage™ Flash 12M column using 0–40% ethyl acetate in hexanes as eluant to give the title compound 9A-1 (145 mg, 79%) as a colorless solid: +ES MS (M+1) 438.3; 1H NMR (CD2Cl2) δ 7.70 (d, J=6.2 Hz, 1H), 7.59–7.56 (m, 1H), 7.52–7.43 (m, 3H), 7.38–7.34 (m, 2H), 7.29–7.25 (m, 3H), 5.03 (br s, 2H).

Provenance & Evidence