HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 2,5-Dichloronicotinate → Methyl 5-chloro-2-(3-(4-(trifluoromethyl)phenoxy)pyrrolidin-1-yl)nicotinate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 2,5-Dichloronicotinate | HCID 2764318 | — |
| Reactant | 3-[4-(Trifluoromethyl)phenoxy]pyrrolidine | HCID 18723127 | — |
| Product | Methyl 5-chloro-2-(3-(4-(trifluoromethyl)phenoxy)pyrrolidin-1-yl)nicotinate | HCID 67958148 | 66% |
Reaction Steps
The title compound (D91) (230 mg) was prepared according to the experimental procedure described in Description 62 starting methyl 2,5-dichloronicotinate (180 mg, 0.87 mmol) and 3-(4-(trifluoromethyl)phenoxy)pyrrolidine (D57) (242 mg, 1.05 mmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08828987B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-e5fd06bc327b4a6da777f36beec5c967 |
| Source note | uspto-grants-2014_09 |