HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 724519Generated: October 30, 2026
Diisopropylethylamine → [2-({2-[2-(2-tert-Butoxycarbonylamino-ethylcarbamoyl)-1H-indol-6-ylcarbamoyl]-1H-indole-5-carbonyl}-amino)-ethyl]-carbamic acid tert-butyl ester
https://huagongshe.com/reaction/724519
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | {2-[(6-Amino-1H-indole-2-carbonyl)-amino]-ethyl}-carbamic acid tert-butyl ester | HCID 69528719 | — |
| Reactant | 5-(2-tert-Butoxycarbonylamino-ethylcarbamoyl)-1H-indole-2-carboxylic acid pentafluorophenyl ester | HCID 86591604 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | [2-({2-[2-(2-tert-Butoxycarbonylamino-ethylcarbamoyl)-1H-indol-6-ylcarbamoyl]-1H-indole-5-carbonyl}-amino)-ethyl]-carbamic acid tert-butyl ester | HCID 58747060 | — |
Reaction Steps
A mixture of above amine 36 and compound 33 (0.226 g, 0.44 mmol) in dry DMF (6 ml) in the presence of DIEA (77 μl, 0.44 mmol) was stirred at 55° C. for 2 days. After removal of solvent, the residue was recrystalized from MeOH-ether to give compound 37 in a quantitative yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07141680B2 |
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| Source dataset | uspto-grants-2006_11 |
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| ORD ID | ord-ec84d62f70c04121a1d14d281c95c94a |
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| Source note | uspto-grants-2006_11 |
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