HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Methyl 2,5-Dichloronicotinate → Methyl 5-chloro-2-(3-(3-(trifluoromethyl)phenoxy)pyrrolidin-1-yl)nicotinate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Methyl 2,5-Dichloronicotinate | HCID 2764318 | — |
| Edukt | 3-[3-(Trifluoromethyl)phenoxy]pyrrolidine | HCID 18337171 | — |
| Produkt | Methyl 5-chloro-2-(3-(3-(trifluoromethyl)phenoxy)pyrrolidin-1-yl)nicotinate | HCID 67958734 | 57,6% |
Reaktionsschritte
The title compound (D92) (270 mg) was prepared according to the experimental procedure described in Description 62 starting methyl 2,5-dichloronicotinate (241.37 mg, 1.17 mmol) and from 3-(3-(trifluoromethyl)phenoxy)pyrrolidine (D58) (323 mg, 1.39 mmol).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08828987B2 |
| Quelldatensatz | uspto-grants-2014_09 |
| ORD ID | ord-c9a7df74075346c4958f67ff3a1054cf |
| Quellennotiz | uspto-grants-2014_09 |