HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Hydroxybenzotriazole → HCID 86591606, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | N-((1,1-dimethylethoxy)carbonyl)-beta-alanine | HCID 76809 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 2733084 | — |
| Reactant | HCID 86591607 | HCID 86591607 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 86591606 | HCID 86591606 | — |
Reaction Steps
Compound 113 was reduced to its amine by hydrogenation according to the procedure for 36. The amine was then reacted with 3-tert-butoxycarbonylaminopropionic acid in the presence of HBTU, HOBt, and DIEA in dry DMF, followed by de-Boc protection according to the procedure for 109 to give 114 in quantitative yield. MS: 241.15 (M/2+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07141680B2 |
| Source dataset | uspto-grants-2006_11 |
| ORD ID | ord-27391a4e2ad64b7bbdd2f86e80507f44 |
| Source note | uspto-grants-2006_11 |