Pyrazole-1-carboxamidine monohydrochloride → HCID 178448562, compound

HRID 724527Notes

Reaction equation

[C:1]([CH2:4][CH2:5][NH:6][C:7]([C:9]1[N:13]([CH2:14][CH:15]([CH3:17])[CH3:16])[CH:12]=[C:11]([NH:18][C:19]([C:21]2[NH:22][C:23]3[C:28]([CH:29]=2)=[CH:27][C:26]([NH:30][C:31](=[O:35])[CH2:32][CH2:33][NH2:34])=[CH:25][CH:24]=3)=[O:20])[CH:10]=1)=[O:8])(=[NH:3])[NH2:2].Cl.[N:37]1([C:42](N)=[NH:43])C=CC=N1>>[C:1]([CH2:4][CH2:5][NH:6][C:7]([C:9]1[N:13]([CH2:14][CH:15]([CH3:17])[CH3:16])[CH:12]=[C:11]([NH:18][C:19]([C:21]2[NH:22][C:23]3[C:28]([CH:29]=2)=[CH:27][C:26]([NH:30][C:31](=[O:35])[CH2:32][CH2:33][NH:34][C:42]([NH2:43])=[NH:37])=[CH:25][CH:24]=3)=[O:20])[CH:10]=1)=[O:8])(=[NH:2])[NH2:3]

Participants

Reactant 2

HCID 2734672Pyrazole-1-carboxamidine monohydrochloride

HCID 86591606HCID 86591606, compound

Product 1

HCID 178448562HCID 178448562, compoundYield 26%

Procedure

Compound 114 was treated with 1H-pyrazole-1-carboxamidine hydrochloride according to the procedure for 47 to give compound 115. Yield: 26%. MS: 262.17 (M/2+H+). 1H-NMR (DMSO-d6): 11.51 (s, 1H), 10.25 (s, 1H), 9.93 (s, 1H), 8.89 & 8.60 (2br s, 3H), 8.25 (t, 1H), 7.99 (s, 1H), 7.51 (t, 1H), 7.37 (d, 1H), 7.26 (d, 1H), 7.25 (s, 1H), 7.19 (d, 1H), 6.92 (d, 1H), 4.11 (d, 2H), 2.59 (t, 2H), 1.98 (m, 1H), 0.80 (d, 6H).

Sources & evidence

ORD record: ord-c0f824aea1d84fb6b66594343a9d1544
Source dataset: uspto-grants-2006_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07141680B2

Reaction notes

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