HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Hydroxybenzotriazole → HCID 86591608, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | N-((1,1-dimethylethoxy)carbonyl)-beta-alanine | HCID 76809 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 2733084 | — |
| Reactant | Anisole trifluoroacetic acid | HCID 66633105 | — |
| Reactant | {2-[(6-Amino-1H-indole-2-carbonyl)-amino]-ethyl}-carbamic acid tert-butyl ester | HCID 69528719 | — |
| Reactant | HCID 69599322 | HCID 69599322 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 86591608 | HCID 86591608 | 96% |
Reaction Steps
Compound 116 was reduced by hydrogenation according to the procedure for compound 36, and then reacted with 3-tert-butoxycarbonylaminopropionic acid in DMF in the presence of HBTU, HOBt, and DIEA, followed by deprotection with TFA/anisole according to the procedure for 108. Compound 117 was obtained in 96% yield. MS: 227.62 (M/2+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07141680B2 |
| Source dataset | uspto-grants-2006_11 |
| ORD ID | ord-478283a7caf24ead86e576830823a8aa |
| Source note | uspto-grants-2006_11 |