Methyl 2,5-Dichloronicotinate → HCID 67958639, compound

HRID 72453Notes

Reaction equation

HRID 72453 reaction equation
Cl[C:2]1[N:11]=[CH:10][C:9]([Cl:12])=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5].[F:13][C:14]1[CH:25]=[CH:24][C:17]([O:18][CH:19]2[CH2:23][CH2:22][NH:21][CH2:20]2)=[CH:16][CH:15]=1>>[Cl:12][C:9]1[CH:10]=[N:11][C:2]([N:21]2[CH2:22][CH2:23][CH:19]([O:18][C:17]3[CH:24]=[CH:25][C:14]([F:13])=[CH:15][CH:16]=3)[CH2:20]2)=[C:3]([CH:8]=1)[C:4]([O:6][CH3:7])=[O:5]

Participants

3

Reactant 2

HCID 2764318Methyl 2,5-DichloronicotinateHCID 218981593-(4-Fluorophenoxy)pyrrolidine

Product 1

HCID 67958639HCID 67958639, compoundYield 57.3%

Procedure

The title compound (D93) (235 mg) was prepared according to the experimental procedure described in Description 62 starting from methyl 2,5-dichloronicotinate (241.37 mg, 1.17 mmol) and 3-(4-fluorophenoxy)pyrrolidine (D59) (253 mg, 1.39 mmol).

Sources & evidence

ORD record
ord-988862631df044b0bf08c5bd14fc25e3
Source dataset
uspto-grants-2014_09
Patent number
US08828987B2

Reaction notes

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