HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 2,5-Dichloronicotinate → Methyl 5-chloro-2-(3-(3-fluorophenoxy)pyrrolidin-1-yl)nicotinate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 2,5-Dichloronicotinate | HCID 2764318 | — |
| Reactant | 3-(3-Fluorophenoxy)pyrrolidine | HCID 45075501 | — |
| Product | Methyl 5-chloro-2-(3-(3-fluorophenoxy)pyrrolidin-1-yl)nicotinate | HCID 67958336 | 60.9% |
Reaction Steps
The title compound (D95) (250 mg) was prepared according to the experimental procedure described in Description 62 starting from methyl 2,5-dichloronicotinate (241.37 mg, 1.17 mmol) and 3-(3-fluorophenoxy)pyrrolidine (D60) (253 mg, 1.39 mmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08828987B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-6acf5286cc4f4c5faa2b3998091409ca |
| Source note | uspto-grants-2014_09 |