Sodium Hydroxide → HCID 21880781, compound

Participants

Reaction Steps

1.3 g (2.4 mmol) 198 was saponified with 5 mL 1M NaOH in 50 mL methanol at room temperature overnight. The methanol was evaporated, the solution was diluted to about 100 mL with cold icy water and was acidified to pH 2 using cold 1 M HCl. The product formed a gel which was extracted with 100 mL ethylacetate, the organic phase was washed once with water and twice with brine, was dried with sodium sulfate and was evaporated to dryness to give a brownish solid foam in quantitative yield. MS: 502.25 (M−H+).

Provenance & Evidence