Methyl 2,5-Dichloronicotinate → HCID 67958737, compound

HRID 72455Notes

Reaction equation

HRID 72455 reaction equation
Cl[C:2]1[N:11]=[CH:10][C:9]([Cl:12])=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5].[C:13]1([CH3:25])[CH:18]=[CH:17][CH:16]=[C:15]([O:19][CH:20]2[CH2:24][CH2:23][NH:22][CH2:21]2)[CH:14]=1>>[Cl:12][C:9]1[CH:10]=[N:11][C:2]([N:22]2[CH2:23][CH2:24][CH:20]([O:19][C:15]3[CH:14]=[C:13]([CH3:25])[CH:18]=[CH:17][CH:16]=3)[CH2:21]2)=[C:3]([CH:8]=1)[C:4]([O:6][CH3:7])=[O:5]

Participants

3

Reactant 2

HCID 2764318Methyl 2,5-DichloronicotinateHCID 183371703-(m-Tolyloxy)pyrrolidine

Product 1

HCID 67958737HCID 67958737, compoundYield 49.3%

Procedure

The title compound (D96) (200 mg) was prepared according to the experimental procedure described in Description 62 starting from methyl 2,5-dichloronicotinate (241.37 mg, 1.17 mmol) and 3-(m-tolyloxy)pyrrolidine (D61) (247.7 mg, 1.39 mmol).

Sources & evidence

ORD record
ord-1fe75444df6e4e8a8dd91d48b3aedac4
Source dataset
uspto-grants-2014_09
Patent number
US08828987B2

Reaction notes

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