反应详情

温度

35 °C

Methyl 5-chloro-2-(3-phenoxyazetidin-1-yl)nicotinate (D75) (305 mg, 0.96 mmol) was dissolved in methanol/tetrahydrofuran (10 ml/10 ml), 5N NaOH (10 ml) was added at 0° C. The resulting reaction mixture was heated to 35° C. for 18 hours then cooled to room temperature and concentrated. Water added (10 ml) and the mixture was acidified with 2.5N HCl (pH1-2). The white solid was collected, washed with water and dried to provide compound (D101) (280 mg) as a white solid.

1. customThe resulting reaction mixture
2. temperaturethen cooled to room temperature
3. concentrationconcentrated
4. additionWater added (10 ml)
5. customThe white solid was collected
6. washwashed with water
7. customdried