HCID 21879345, compound → HCID 58746782, compound

HRID 724608Notes

Reaction equation

HRID 724608 reaction equation
FC(F)(F)C(O)=O.[NH2:8][C@@H:9]([CH2:32][C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)[C:10]([NH:12][C@H:13]([C:29](=[O:31])[NH2:30])[CH2:14][C:15]1[CH:20]=[CH:19][C:18]([C:21]2[S:25](=[O:27])(=[O:26])[NH:24][C:23](=[O:28])[CH:22]=2)=[CH:17][CH:16]=1)=[O:11].[CH2:39]([O:41][P:42]([C:47]([F:59])([F:58])[C:48]1[CH:53]=[CH:52][C:51]([CH2:54][C:55](O)=[O:56])=[CH:50][CH:49]=1)([O:44][CH2:45][CH3:46])=[O:43])[CH3:40]>>[CH2:39]([O:41][P:42]([C:47]([C:48]1[CH:49]=[CH:50][C:51]([CH2:54][C:55](=[O:56])[NH:8][C@H:9]([C:10](=[O:11])[NH:12][C@H:13]([C:29](=[O:31])[NH2:30])[CH2:14][C:15]2[CH:16]=[CH:17][C:18]([C:21]3[S:25](=[O:27])(=[O:26])[NH:24][C:23](=[O:28])[CH:22]=3)=[CH:19][CH:20]=2)[CH2:32][C:33]2[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=2)=[CH:52][CH:53]=1)([F:59])[F:58])(=[O:43])[O:44][CH2:45][CH3:46])[CH3:40]

Participants

3

Reactant 2

HCID 21879345HCID 21879345, compoundHCID 69597712HCID 69597712, compound

Product 1

HCID 58746782HCID 58746782, compound

Procedure

This compound was prepared according to the procedure of Example 1.1, Step 10, using 1.38-B of Step 2 and {4-[(diethoxy-phosphoryl)-difluoro-methyl]-phenyl}-acetic acid (Biochemistry, 2003, 42, 12792) as the starting materials. LCMS found for C34H38F2N4O9PS (M+H)+: m/z=747.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-94f8be3c416f4f11b1247b0c4225edf9
Source dataset
uspto-grants-2006_11
Patent number
US07141596B2

Reaction notes

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