Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2,4-Difluorophenol → 5-Chloro-2-(3-(2,4-difluorophenoxy)azetidin-1-yl)nicotinic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2,4-Difluorophenol | HCID 123051 | — |
| 반응물 | Methyl 5-chloro-2-(3-((methylsulfonyl)oxy)azetidin-1-yl)nicotinate | HCID 86697874 | — |
| 생성물 | 5-Chloro-2-(3-(2,4-difluorophenoxy)azetidin-1-yl)nicotinic acid | HCID 67958422 | 86.8% |
반응 단계
The title compound (D108) (84 mg) was prepared according to the experimental procedure described in Description 103A starting from methyl 5-chloro-2-(3-((methylsulfonyl)oxy)azetidin-1-yl)nicotinate (D63) (100 mg, 0.311 mmol) and 2,4-Difluorophenol (0.027 ml, 0.284 mmol).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08828987B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-44d3865ae6cf493b9657033d0acad975 |
| 출처 메모 | uspto-grants-2014_09 |