HCID 58746756, compound → HCID 69597698, compound

Participants

Reaction Steps

A solution of 401-A (50 mg, 0.07 mmol) and 5% Pd/BaSO4 (5 mg, 10 wt %) in ethanol (1.5 mL), methanol (1.0 mL) and dichloromethane (2 drops) was stirred under an atmosphere of hydrogen for 5 h. The reaction mixture was filtered and concentrated to yield the 401-B (48 mg, 96%) as a white solid. 1H NMR (500 MHz, CDCl3): δ 7.30–7.26 (m, 4H), 7.22–7.16 (m, 4H), 7.00–6.94 (m, 4H), 6.85–6.81 (m, 2H), 6.43 (dd, J=8.3, 4.9 Hz, 1H), 5.90–5.84 (m, 1H), 5.79 (dd, J=8.8, 6.8 Hz, 1H), 4.75 (ddd, J=10.7, 9.3, 2.0 Hz, 1H), 4.61–4.57 (m, 1H), 4.50 (dd, J=12.2, 6.3 Hz, 1H), 3.82 (s, 3H), 3.43–3.35 (m, 2H), 3.22–3.09 (m, 4H), 3.05–3.03 (m, 1H), 3.00–2.90 (m, 1H), 2.90–2.80 (m, 1H), 1.66 (s, 9H), 1.40–1.35 (m, 2H), 1.35–1.23 (m, 2H), 1.23–1.17 (m, 2H), 0.88 (t, J=7.1 Hz, 3H); LCMS found for C39H51N4O7S (M+H)+: m/z=719.

Provenance & Evidence