Bromotrimethylsilane → 4'-Bromomethyl-4-methanesulfonyl-biphenyl

Participants

Role	Name	HCID	Charge
Reactant	Bromotrimethylsilane	HCID 76113	—
Reactant	[4'-(Methylsulfonyl)[1,1'-biphenyl]-4-yl]methanol	HCID 21878562	—
Solvent	1,4-Dioxane	HCID 31275	—
Product	4'-Bromomethyl-4-methanesulfonyl-biphenyl	HCID 21878868	95.4%

Reaction Conditions

Temperature	25 °C

Reaction Steps

A solution of (4′-methanesulfonyl-biphenyl-4-yl)-methanol (129 mg, 0.49 mmol) in 1,4-dioxane (5 mL) was treated with bromotrimethylsilane (0.2 mL, 1.5 mmol) and stirred at 25° C. for 16 h. The reaction mixture was concentrated and purified by flash column chromatography to yield 4.15-B (152 mg, 95%) as a yellow solid. LCMS found for C14H14BrO2S (M+H)+: m/z=326.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07141596B2
Source dataset	uspto-grants-2006_11
ORD ID	ord-f82444c3665140e58266c7d4a8ed0068
Source note	uspto-grants-2006_11