Trifluoroacetic acid → HCID 131726124, compound

Participants

Reaction Steps

A solution of 411-G of Example 4.11 (11 mg, 13 μmol) and triisopropylsilane (250 mL, 1.2 mmol) in trifluoroacetic acid (1.3 mL) was heated in a microwave at 170° C. for four minutes. The reaction mixture was diluted with toluene (5 mL) and evaporated. This was repeated until a residue appeared which was purified by preparative LCMS to yield the desired product (1.6 mg, 18%). 1H NMR (500 MHz, CD3OD): δ 7.46 (dd, J=8.8, 4.4 Hz, 1H), 7.32 (dd, J=9.3, 2.0 Hz, 1H), 7.19 (s, 1H), 7.14 (s, 1H), 7.08–7.04 (s, 1H), 5.44 (dd, J=8.8, 8.3 Hz, 1H), 4.03–3.98 (m, 1H), 3.98–3.84 (m, 2H), 3.79–3.70 (m, 1H), 3.52–3.42 (m, 1H), 3.41–3.39 (m, 1H), 3.33–3.27 (m, 1H), 3.13–3.01 (m, 3H); LCMS found for C20H20FN4O4S2 (M+H)+: m/z=463.

Provenance & Evidence