HCID 69598138, compound → HCID 58746608, compound

Participants

Reaction Steps

To a solution of (2S)-2-(acetylamino)-N-{(1R)-1-(1H-benzimidazol-2-yl)-2-[4-(1,1-dioxido-3-oxo-2,3-dihydroisothiazol-5-yl)phenyl]ethyl}-3-phenylpropanamide (5.0 mg, 0.009 mmol) in methanol (1.5 mL) was added 5% palladium on carbon (3 mg, 0.03 mmol), and mixed for 1.5 h under hydrogen gas (50 psi). Product was filtered and purified by preparative LCMS to afford the final product (1.9 mg, 38%). 1H NMR (500 MHz, CD3OD): δ 7.73–7.76 (m, 2H), 7.58–7.60 (m, 2H), 7.43 (d, J=7.0 Hz, 2H), 7.23–7.26 (m, 5H), 7.14–7.16 (m, 2H), 5.42–5.47 (m, 1H), 5.11–5.16 (m, 1H), 4.52–4.56 (m, 1H), 3.40–3.46 (m, 2H), 2.76–2.92 (m, 4H), 1.90 (s, 3H); LCMS found for C29H30N5O5S (M+H)+: m/z=560.1

Provenance & Evidence