HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Fluoroaniline → 5-Chloro-2-(3-((3-fluorophenyl)amino)azetidin-1-yl)nicotinic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Fluoroaniline | HCID 9742 | — |
| Reactant | Methyl 5-chloro-2-(3-((methylsulfonyl)oxy)azetidin-1-yl)nicotinate | HCID 86697874 | — |
| Product | 5-Chloro-2-(3-((3-fluorophenyl)amino)azetidin-1-yl)nicotinic acid | HCID 67958101 | 33.2% |
Reaction Steps
The title compound (D116) (40 mg) was prepared according to the experimental procedure described in Description 115 starting from methyl 5-chloro-2-(3-((methylsulfonyl)oxy)azetidin-1-yl)nicotinate (D63) (120 mg, 0.374 mmol) and 3-Fluoroaniline (0.036 ml, 0.374 mmole).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08828987B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-ceca98f8efd74ece85f4fe9fa8fdb09c |
| Source note | uspto-grants-2014_09 |