Pyridine → 1-[2-bromo-4-(methoxycarbonyl)phenyl]-3-methoxy-3-oxopropane-1-sulfonic Acid pyridine

HRID 724676Notes

Reaction equation

HRID 724676 reaction equation
[Br:1][C:2]1[CH:7]=[C:6]([C:8]([O:10][CH3:11])=[O:9])[CH:5]=[CH:4][C:3]=1[CH:12]([S:18]([OH:21])(=[O:20])=[O:19])[CH2:13][C:14]([O:16][CH3:17])=[O:15].C(OC(=O)C)(=O)C.[N:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1>>[Br:1][C:2]1[CH:7]=[C:6]([C:8]([O:10][CH3:11])=[O:9])[CH:5]=[CH:4][C:3]=1[CH:12]([S:18]([OH:21])(=[O:19])=[O:20])[CH2:13][C:14]([O:16][CH3:17])=[O:15].[N:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1

Participants

4

Reactant 3

HCID 1049PyridineHCID 7918Acetic AnhydrideHCID 218785661-[2-bromo-4-(methoxycarbonyl)phenyl]-3-methoxy-3-oxopropane-1-sulfonic Acid

Product 1

HCID 866020801-[2-bromo-4-(methoxycarbonyl)phenyl]-3-methoxy-3-oxopropane-1-sulfonic Acid pyridine

Procedure

To a flask contained 1-[2-bromo-4-(methoxycarbonyl)phenyl]-3-methoxy-3-oxopropane-1-sulfonic acid (0.78 g, 2.0 mmol) was added acetic anhydride (0.965 mL, 10.2 mmol) and pyridine (0.496 mL) at room temperature. The mixture was stirred at room temperature overnight. The salt was precipitated by addition of diethyl ether, isolated by filtration. The crude product was used in next step.

Workup

  1. customTo a flask contained
  2. customThe salt was precipitated by addition of diethyl ether
  3. customisolated by filtration

Sources & evidence

ORD record
ord-a868b50ab51940e3884626929f71c7be
Source dataset
uspto-grants-2006_11
Patent number
US07141596B2

Reaction notes

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