反应详情

温度

60 °C

To a solution of methyl 5-chloro-2-(3-(methyl(2-methyl-4-fluoro-phenyl)amino)azetidin-1-yl)nicotinate (D87) (170 mg, 0.467 mmol) in 1,4 dioxane (3 ml) and water (1 ml) 1M NaOH (0.7 ml) was added. The mixture was stirred at 60° C. for 2 h. Organic solvent was evaporated and remaining aqueous were acidified 2N HCl and extracted with ethylacetate (3×5 ml). The combined organic phases after solvent evaporation afforded the title compound (D120) (156 mg)

1. customOrganic solvent was evaporated
2. extractionextracted with ethylacetate (3×5 ml)
3. customThe combined organic phases after solvent evaporation